Working Around the Problem: The Impact of Being Overweight and Obese on the Treatment of Clinical Illness

  • Sarel Brand North-West University
  • Linda Brand North-West University
  • De Wet Wolmarans North-West University
Keywords: overweight, obese, clinical illnesses


Overweight and obesity are not only two highly prevalent conditions in the South African society, but they also contribute to 6 of the 10 most common causes of death. Further, being overweight not only results in significant metabolic and endocrine disturbances, it also changes how patients respond to most pharmacotherapeutic interventions for clinical illness. The present paper will attempt to elucidate some of the most common physio-pathological phenomena associated with being overweight and obese. We will briefly focus on the manner in which especially excessive visceral adipose tissue contributes to an altered physiological state and pharmacokinetic profile, while highlighting important clinical aspects of comorbid conditions that are frequently observed in this patient cohort.

Author Biographies

Sarel Brand, North-West University
Unit for Environmental Sciences and Management North-West University Potchefstroom
Linda Brand, North-West University
Center of Excellence for Pharmaceutical Sciences North West-University Potchefstroom
De Wet Wolmarans, North-West University
Centre of Excellence for Pharmaceutical Sciences Division of Pharmacology Faculty of Health Sciences North-West University Potchefstroom
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